Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study.

Mar 9, 2020

Apart from the known efficacy of Botulinum Neurotoxin Type A (BoNT/A) in hyperactive striated and...

Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes.

Mar 9, 2020

Astrocytes mediate a remarkable variety of cellular functions, including gliotransmitter release....

Remission in psoriatic arthritis: Definition and predictors.

Mar 9, 2020

To determine the frequency of remission defined by the absence of the various disease manifestations of psoriatic arthritis (PsA) and identify predictors for remission.Patients followed at the PsA clinic between 2000 and 2015...

Nerve growth factor promotes ASIC1a expression via the NF-κB pathway and enhances acid-induced chondrocyte apoptosis.

Mar 9, 2020

Nerve growth factor (NGF) is a neurotrophic factor that is thought to have a broad role in the nervous system and tumors, and has recently been described as a mediator of inflammation. It is not clear whether or not NGF...

Differential impact of psychological and psychophysical stress on low back pain in mice.

Mar 9, 2020

Low back pain (LBP) is a highly prevalent and disabling condition whose initiating factors are poorly understood. It is known that psychological and physical stress is associated with LBP but the causal relationship, mechanisms...

Alcohol-aggravated episodic pain in humans with SCN11A mutation and ALDH2 polymorphism.

Mar 9, 2020

Mutations in Nav1.9 encoded by SCN11A have been associated with episodic pain, small-fiber neuropathy and congenital insensitivity to pain. In this study, we collected and characterized one Chinese family with episodic pain. The...

Parent cognitive, behavioural, and affective factors and their relation to child pain and functioning in pediatric chronic pain: a systematic review and meta-analysis.

Mar 9, 2020

Prior studies have demonstrated that parental cognitive, behavioral and emotional factors are related to child functioning in children and adolescents with chronic pain. This is particularly important to understand how to...

Non-surgical mouse model of endometriosis-associated pain that responds to clinically active drugs.

Mar 9, 2020

Endometriosis is an estrogen-dependent inflammatory disease that affects approximately 10% of women. Debilitating pelvic or abdominal pain is one of its major clinical features. Current animal models of endometriosis-associated...

Implant survival in uncemented total hip arthroplasty for displaced intracapsular femoral neck fractures: outcomes of 115 patients in a single center.

Mar 9, 2020

There remains disagreement about the use of cemented or uncemented total hip arthroplasty (THA) for patients with a displaced intracapsular femoral neck fracture (FNF). The aim of this study was to assess implant survival,...

The Achilles tendon Total Rupture Score is a responsive primary outcome measure: an evaluation of the Dutch version including minimally important change.

Mar 9, 2020

Aim of this study was to evaluate the responsiveness of the Dutch version of the Achilles tendon Total Rupture Score (ATRS-NL).Patients (N = 47) completed the ATRS-NL at 3 and 6 months after Achilles tendon rupture (ATR)....

Enhancement of chondrogenic differentiation supplemented by a novel small compound for chondrocyte-based tissue engineering.

Mar 9, 2020

Chondrocyte -based tissue engineering has been a promising option for the treatment of cartilage lesions. In previous literature, TD198946 has been shown to promote chondrogenic differentiation which could prove useful in...

Uptake of an exercise class and use of bone density measurement after advice by the health insurance fund: results from the osteoporotic fracture prevention program in rural areas (OFRA).

Mar 9, 2020

OFRA is a large health insurance fund-driven program which aims to reduce the risk of falls and...

Association between the dimensions of the maxillary sinus membrane and molar periodontal status: A retrospective CBCT study.

Mar 9, 2020

The information of the association between residual alveolar bone height and mucosal thickening is sparse. This study aimed to explore the effect of maxillary molar periodontal status on sinus mucosal thickening using cone-beam...

Development and Characterization of a Benchtop Corneal Puncture Injury Model.

Mar 9, 2020

During recent military operations, eye-related injuries have risen in frequency due to increased...

Data-driven modelling and spatial complexity supports heterogeneity-based integrative management for eliminating Simulium neavei-transmitted river blindness.

Mar 9, 2020

Concern is emerging regarding the challenges posed by spatial complexity for modelling and...

Five-year outcomes of small-incision lenticule extraction vs femtosecond laser-assisted laser in situ keratomileusis: a contralateral eye study.

Mar 9, 2020

To compare the long-term refractive and visual outcomes and the corneal higher-order aberrations of contralateral eyes of patients who received small-incision lenticule extraction (SMILE) in one eye and femtosecond...