The present study was done as a systematic review and meta‐analysis. The aim was to establish the possible value of CSF and serum/plasma levels of amino acids as PD markers.
This study was a literature review of 4 databases. The researchers reviewed databases that included PubMed, Embase, MEDLINE, and Web of Science – Core Collection, identifying references of interest for the topic. The meta‐analysis of eligible studies was done using R software package meta, following the PRISMA and MOOSE guidelines.
When the focus group was compared with controls, PD patients showed decreased CSF levels of glutamate and taurine and increased CSF levels of tyrosine; decreased serum/plasma levels of aspartate, serine, tryptophan, and lysine, and increased serum/plasma proline and homocysteine levels.
The study concluded through its findings that despite the limitations of this study due to the critical variability of results between different series. The research suggests the value of CSF or serum/plasma levels of several amino acids in the discrimination of PD patients from healthy subjects related to some amino acids’ stories.
Reference: https://onlinelibrary.wiley.com/doi/10.1111/ene.14470
