Continuous hypothermic machine perfusion during organ preservation is found to be beneficial on graft function and survival compared with static cold storage (SCS) in kidney transplants. This study aims to compare the effect of SCS followed by short-term oxygenated hypothermic machine perfusion preservation (end-HMPo2) or SCS alone on 1-year graft survival of the organ for a kidney transplant.
This randomized, prospective, multicenter trial includes 305 kidneys from expanded criteria donors. The kidneys were randomized to either SCS or SCS followed by end-HMPo2 before transplantation. The minimum machine perfusion time was 120 minutes. The primary outcome of the study was one-year graft survival, along with patient survival.
The findings suggested that 262 kidneys (48.5%) in the end-HMPo2 were successfully transplanted compared to 135 (41.5%) in the SCS group. The median cold ischemia time was 13.2 hours in the end-HMPo2 group and 12.9 hours in the SCS group. The median duration in the end-HMPo2 was 4.7 hours. The one-year graft survival rate was 92.1% in the end-HMPo2 group compared to 93.3% in the SCS group. The primary and secondary endpoint analyses showed no significant difference between the two groups.
The research concluded that end-HMPo2 after SCS was not associated with greater graft survival.
Ref: https://jamanetwork.com/journals/jamasurgery/article-abstract/2778929?resultClick=1
