MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease.

May 17, 2021

Contributor: Joel Ramirez,Melissa F Holmes,Courtney Berezuk,Donna Kwan,Brian Tan,Derek Beaton,Christopher J M Scott,Miracle Ozzoude,Fuqiang Gao,Di Yu,Walter Swardfager,Jane Lawrence-Dewar,Dar Dowlatshahi,Gustavo Saposnik,Mark I Boulos,Brian J Murray,Sean Symons,Robert Bartha,Sandra E Black,Richard H Swartz, ,Andrew Lim

MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease.

Recent studies suggest that interindividual genetic differences in glial-dependent CSF flow through the brain parenchyma, known as glymphatic flow, may trigger compensatory changes in human sleep physiology. In animal models, brain perivascular spaces are a critical conduit for glymphatic flow. We tested the hypothesis that MRI-visible PVS volumes, a putative marker of perivascular dysfunction, are associated with compensatory differences in real-world human sleep behavior.
We analyzed data from 152 cerebrovascular disease patients from the Ontario Neurodegenerative Disease Research Initiative (ONDRI). PVS volumes were measured using 3T-MRI. Self-reported total sleep time, time in bed, and daytime dysfunction were extracted from the Pittsburgh Sleep Quality Index.
Individuals with greater PVS volumes reported longer time in bed (+0.85 h per log10 proportion of intracranial volume (ICV) occupied by PVS, SE = 0.30, p = 0.006) and longer total sleep times (+0.70 h per log10 proportion of ICV occupied by PVS volume, SE = 0.33, p = 0.04), independent of vascular risk factors, sleep apnea, nocturnal sleep disturbance, depression, and global cognitive status. Further analyses suggested that the positive association between PVS volumes and total sleep time was mediated by greater time in bed. Moreover, despite having on average greater total sleep times, individuals with greater basal ganglia PVS volumes were more likely to report daytime dysfunction (OR 5.63 per log10 proportion of ICV occupied by PVS, 95% CI: 1.38-22.26, p = 0.018).
Individuals with greater PVS volumes spend more time in bed, resulting in greater total sleep time, which may represent a behavioral compensatory response to perivascular space dysfunction.

Copyright © 2021 Elsevier B.V. All rights reserved.

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About The Expert

Joel Ramirez

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. Electronic address: joel.ramirez1@sunnybrook.ca.

Melissa F Holmes

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

Courtney Berezuk

Psychological Clinical Science, University of Toronto Scarborough, ON, Canada.

Donna Kwan

Queen’s University, Centre for Neuroscience Studies, Kingston, ON, Canada.

Brian Tan

Rotman Research Institute, Baycrest Health Sciences Centre, Toronto, ON, Canada.

Derek Beaton

Rotman Research Institute, Baycrest Health Sciences Centre, Toronto, ON, Canada.

Christopher J M Scott

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

Miracle Ozzoude

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

Fuqiang Gao

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

Di Yu

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.

Walter Swardfager

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.

Jane Lawrence-Dewar

Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada.

Dar Dowlatshahi

Department of Medicine (Neurology), Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

Gustavo Saposnik

Stroke Outcomes and Decision Neuroscience Research Unit, Division of Neurology, St. Michael’s Hospital, University of Toronto, ON, Canada.

Mark I Boulos

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada.

Brian J Murray

Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada.

Sean Symons

Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Robert Bartha

Centre for Functional and Metabolic Mapping, Robarts Research Institute, Department of Medical Biophysics, University of Western Ontario, ON, Canada.

Sandra E Black

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada.

Richard H Swartz

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada.

Andrew Lim

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada.

References

PubMed