This study states that Glucagon‐like peptide 1 receptor agonists (GLP‐1 RA) have recently shown improved proportions of memory and decreased phospho‐tau trouble in preclinical creature models applicable to reformist intellectual weakness To examine the expected impacts of GLP‐1 RA on dementia in a clinical setting, a post‐hoc investigation was directed dependent on pooled information from three CVOTs.
Pioneer, SUSTAIN 6 and PIONEER 6 were randomized, double‐blind, multicentre, placebo‐controlled CVOTs assessing the cardiovascular impact of liraglutide or semaglutide versus fake treatment, added to standard of care. The preliminaries included patients with type 2 diabetes and set up or high danger of cardiovascular infection. A post‐hoc examination on pooled information from the three CVOTs was considered fitting because of the likenesses in preliminary plan, patient populace and treatment impacts. Across all preliminaries 15,820 patients with middle follow‐up of 3.6 years were remembered for this investigation. Dementia‐related antagonistic occasions (AEs) were distinguished utilizing Standardized MedDRA Query for “dementia” restricted inquiry terms. AE information assortment across the preliminaries contrasted in accordance with the administrative necessities at the hour of preliminary direct. In LEADER and PIONEER 6 just genuine AEs were methodicallly gathered, while all AEs were gathered in SUSTAIN 6.
Reference link- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.042909
