The aim is To estimate serum pro-renin, and its clinical significance, as a marker of chronic renal disease in posterior urethral valve (PUV) patients. Forty patients with a PUV that were admitted to the hospital between 2010 and 2012 were reviewed. Twenty age-matched patients who were admitted for other non-urological diseases were selected for control. Clinical parameters, serum creatinine, urea, eGFR (estimated glomerular filtration rate) and serum pro-renin were analysed before and after valve ablation. Forty patients with PUV were included in the study. Three groups were formed according to age: <1 year, 1–3 years, >3 years. Pro-renin was measured using an ELISA (enzyme linked immunosorbent assay) kit and ‘Graph Pad Prism’ Software. The Spearman’s rho test was used for correlation. Serum pro-renin had a negative correlation with the age group (correlation coefficient −0.395, P-value 0.012), eGFR (correlation coefficient −0.850, P-value < 0.001) and follow-up eGFR (correlation coefficient −0.471, P-value 0.002). The pro-renin level correlated positively with serum creatinine at presentation (correlation coefficient 0.671, P-value < 0.001), blood urea at initial presentation (correlation coefficient 0.684, P-value < 0.001), serum creatinine at follow-up (correlation coefficient 0.546, P-value < 0.001) and blood urea at follow-up (correlation 0.603, P-value < 0.001).
Reference link- https://www.sciencedirect.com/science/article/abs/pii/S1477513114001764
