Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.
To determine whether vitamin D supplementation reduces levels of total IgE and IgE to each of two common indoor allergens in children with asthma and low vitamin D levels.
Total IgE, IgE to Dermatophagoides pteronyssinus (Der p), and IgE to Blattella germanica (Bla g) were measured at the randomization and exit visits for 174 participants in the Vitamin D Kids Asthma study (VDKA), a multicenter, double-blind, randomized placebo-controlled trial of vitamin D supplementation (4,000 IU/day) to prevent severe exacerbations in children with persistent asthma and vitamin D levels <30 ng/ml. Multivariable linear regression was used for the analysis of the effect of vitamin D supplementation on change in each IgE measure.
Participants were followed for an average of 316 days. At the exit visit, more subjects in the vitamin D arm achieved a vitamin D level ≥30 ng/ml compared to those in the placebo arm (87% vs. 30%, P<0.001). In a multivariable analysis, vitamin D supplementation had no significant effect on change in total IgE, IgE to Der p, or IgE to Bla g between the exit and randomization visits (e.g., for log total IgE, ß=0.007, 95% confidence interval= -0.061 to 0.074, P=0.85).
Vitamin D supplementation, compared to placebo, has no significant effect on serum levels of total IgE, IgE to dust mite, or IgE to cockroach in children with asthma and low vitamin D levels.

Copyright © 2021. Published by Elsevier Inc.

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