Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort.

Aug 5, 2021

Contributor: Xiaomeng Chu,Li Liu,Jing Ye,Yan Wen,Ping Li,Bolun Cheng,Shiqiang Cheng,Lu Zhang,Xin Qi,Mei Ma,Chujun Liang,Om Prakash Kafle,Cuiyan Wu,Sen Wang,Xi Wang,Yujie Ning,Feng Zhang

Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort.

We aim to explore the mechanism of relationship between insomnia and liver metabolism by examining the gene × insomnia interactions.
Individual level genotypic and phenotypic data were obtained from the UK Biobank cohort. Regression analysis was first conducted to test the association of insomnia with plasma total bilirubin (TBil; n = 186,793), direct bilirubin (DBil; n = 159,854) and total protein (TP; n = 171,574) in UK Biobank cohort. Second, genome-wide gene-environment interaction study (GWGEIS) was conducted by PLINK 2.0, and FUMA platform was used to identify enriched pathway terms.
In UK Biobank cohort, we found that TP (P < 2.00 × 10), DBil (P = 1.72 × 10) and TBil (P = 3.38 × 10) were significantly associated with insomnia. GWGEIS of both DBil and TBil observed significant G × INSOMNIA effects between insomnia and UDP Glucuronosyltransferase Family 1 (rs6431558, P = 6.26 × 10) gene. GWGEIS of TP also detected several significant genes interacting with insomnia, such as KLF15, (rs70940816, P = 6.77 × 10) and DOK7, (rs2344205, P = 1.37 × 10). Multiple gene ontology (GO) terms were identified for bilirubin, such as GO_URONIC_ACID_METABOLIC_PROCESS (adjusted P = 4.15 × 10).
Our study results suggested negative associations between insomnia and DBil and TBil; and a positive association between insomnia and TP.

Copyright © 2021 Elsevier B.V. All rights reserved.

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About The Expert

Xiaomeng Chu

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Li Liu

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Jing Ye

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Yan Wen

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Ping Li

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Bolun Cheng

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Shiqiang Cheng

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Lu Zhang

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Xin Qi

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Mei Ma

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Chujun Liang

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Om Prakash Kafle

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Cuiyan Wu

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Sen Wang

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Xi Wang

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Yujie Ning

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China.

Feng Zhang

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China. Electronic address: fzhxjtu@mail.xjtu.edu.cn.

References

PubMed