Idiopathic intracranial hypertension (IIH) is a disease characterised by elevated intracranial pressure for unexplained reasons. It manifests as a chronic headache, pulsatile tinnitus, and visual obscuration. It most commonly affects obese women of reproductive age, and the biggest risk is permanent eyesight loss. Some dermatological medicines, particularly those used to treat acne vulgaris, have been linked to IIH. The goal of this study was to critically evaluate all published cases of IIH and identify high-risk drugs associated with drug-induced intracranial hypertension (DIIH), in order to help dermatologists and other physicians with patient education and monitoring of secondary intracranial hypertension symptoms. A total of 5117 items were discovered, with 235 of them being relevant. All cases were evaluated to see if they met the modified Dandy criteria for IIH diagnosis, and the chance of each case being a definite adverse drug reaction (ADR) was calculated using the Koh ADR algorithm. Based on the number of instances that met these two criteria, an association category was allocated. The most strongly linked with DIIH were vitamin A compounds, tetracycline-class antibiotics, recombinant growth hormone, and lithium. Corticosteroids were shown to be modestly related to DIIH. Cyclosporine, progestin-only contraceptives, combined oral contraceptives, second- and third-generation fluoroquinolones, sulfenazone, gonadotropin-releasing hormones and luteinizing hormone-releasing hormone agonist, nalidixic acid, amiodarone, stanozolol, danazol, divalproic acid, sulfasalazine, ketoconazole, and us
Researchers propose a name for drug-induced intracranial hypertension (DIIH) and a set of diagnostic criteria for DIIH. The review tries to identify DIIH-associated medications using a rigorous diagnostic and drug-causality criteria, then classify them according to their risk level. This might eventually help clinicians educate patients about the risk of DIIH while prescribing medicines and detecting this rare but potentially blinding disease.
Reference:https://link.springer.com/article/10.1007/s40257-019-00485-z
