As no data to our knowledge exists, the aim of the study was to describe the national prevalence and characteristics of Danish children and adolescents with severely impaired lung function.
We performed a descriptive, cross-sectional Danish multi-centre study. Children and adolescents between 6-18 years old demonstrating severely impaired lung function from 2015-2018, defined by forced expiratory volume in 1 second (FEV ) <60% or who had lung transplantation were eligible for inclusion.
This study included 113 children with a mean age (standard deviation) of 12.9 years (3.5 years). The prevalence of severely impaired lung function was approximately 13 in 100,000. The mean (standard deviation) FEV was 46.1% (10.1%) of predicted and z-score was -4.5 (0.8). The most frequent diagnosis was cystic fibrosis (20.4%), followed by asthma (19.5%) and bronchiolitis obliterans (16.8%), while almost 25% had different elements of airway malformations or non-pulmonary conditions. Two adolescents with cystic fibrosis underwent lung transplantation.
The estimated prevalence of severely impaired lung function in Danish children and adolescents was low and extremely few children underwent lung transplantation. The most frequent diagnosis was cystic fibrosis, while almost 25% had different elements of airway malformations or non-pulmonary conditions, which may require clinical attention.

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