Lifestyle factors are predictive of the risk for incident psoriasis, regardless of genetic risk, according to a study published in the Journal of the American Academy of Dermatology. Minxue Shen, PhD, and colleagues used data from 500,000 participants to examine the gene-behavior interaction in association with incident psoriasis. Genetic risk was classified as low, intermediate, or high. Lifestyle, which included BMI, smoking, physical activity, and diet, was classified as ideal, intermediate, or poor. The risks for incident psoriasis associated with each lifestyle category were examined within each genetic risk group. The HR was up to 4.625 in association with poor lifestyle and high genetic risk compared with low genetic risk and ideal lifestyle. No interaction was seen between genetic risk and lifestyle. The population-attributable fractions were 32.2% and 13.0% for lifestyle and genetic risk, respectively.
