For a study, it is essential to analyze the postoperative and oncologic results of pelvic exenteration for non-ovarian gynecologic cancers. From January 1, 2010, through December 31, 2019, researchers looked back on the cases of patients who had pelvic exenteration for gynecologic cancers other than ovarian cancer. No survival study was performed on patients who had undergone exenteration for palliative purposes. Early (≤30 days) or late (31–180 days) postoperative problems. A reliable institutional scale was used to rate the severity of complications. Complications greater than or equal to a grade 3 were regarded as serious.
The chi-square test was used to compare categorical variables, and the Kaplan-Meier technique was used to analyze survival data. Recurrent disease was the reason for pelvic exenteration in 89 of the 100 patients, whereas palliation, primary disease, and chronic disease were the reasons in the other 10. Cervical cancer affected 30%, vulvar cancer 27%, uterine cancer 24%, and vaginal cancer 19%. About 62% had a full exenteration, 30% had an anterior exenteration, and 8% had a posterior exenteration. There were no deaths during surgery or in the subsequent 30 days. At the 30-day mark, 6 patients had already passed away. About 197 patients had complications during the surgical procedure, with 49 having them immediately after the operation, 1 having them hours later, and 47 having them both before and after.
Out of the 50, 19 (38%) had a late complication, 22 (44%) had an early complication, and 9 (18%) had both. There was no statistically significant correlation between any of the investigated factors and the occurrence of complications. Progression-free survival after 3 years was 61.0%, while overall survival after 3 years was 61.6%. After 5 and 10 years, 16 (28%) and 4 (7%) of the 58 survivors were still with us. As a whole, the rate of complications after pelvic exenteration remains high. Nearly 100% of cases included complications, although no factors were found to be associated with their occurrence. Improvements in perioperative care are probably responsible for the reduced perioperative death rate.
Source: sciencedirect.com/science/article/abs/pii/S0090825822005716
