Osteogenic effect of low-intensity pulsed ultrasound on peri-implant bone: A systematic review and meta-analysis.

Jul 31, 2023

Experts: Yingying Wang,Ximeng Cao,Yingyi Shen,Qi Zhong,Yujie Huang,Yifan Zhang,Qingfeng Huang,Chun Xu

This study aimed to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) on promoting osseointegration around dental implants.
A comprehensive search was performed on two databases, including MEDLINE (PubMed) and Web of Science to identify relevant studies published before June 1, 2022. Randomized controlled trials that met the inclusion criteria were selected for the study. The year of publication, study design, animal species, number of animals, number of implants, implant position, implant size, intervention, follow-up time, bone volume ratio (BV/TV), bone-implant contact ratio (BIC), and implant removal torque value (RTV) measurements, including mean and SD, were extracted.
Ten randomized trials were included in this meta-analysis. The results showed that LIPUS significantly promoted osteogenesis around dental implants. Furthermore, in animal models of pre-existing diseases such as osteoporosis and diabetes, LIPUS had the same effect. The included data were divided into subgroups to explore the effects of different follow-up time, acoustic intensities, and frequencies. Results showed that higher acoustic intensities and frequencies significantly improve the osteogenic effects of LIPUS. There was some degree of heterogeneity owing to bias in the included studies. More high-quality randomized controlled trials are necessary in the future.
LIPUS can promote bone healing around dental implants and is an attractive option for edentulous patients, especially those with pre-existing diseases. Further clinical trials on the use of LIPUS in implant dentistry are warranted. Furthermore, future studies must pay more attention to acoustic intensity and frequency.

Author

admin

View all posts

ABOUT THE EXPERTS

Yingying Wang,Ximeng Cao,Yingyi Shen,Qi Zhong,Yujie Huang,Yifan Zhang,Qingfeng Huang,Chun Xu

Yingying Wang

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Ximeng Cao

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Yingyi Shen

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Qi Zhong

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Yujie Huang

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Yifan Zhang

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Qingfeng Huang

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Chun Xu

Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

National Center for Stomatology and National Clinical Research Center for Oral Diseases, Shanghai, China.

Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.