High myopia is protective against diabetic retinopathy in the participants of the National Health and Nutrition Examination Survey.

Nov 20, 2023

Experts: Weijung Ten,Ying Yuan,Wei Zhang,Yue Wu,Bilian Ke

To investigate the association of subjects with refractive error and diabetic retinopathy (DR) in the United States comparing results between different race groups.
All data were derived from National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. The data were divided into four groups (emmetropia, mild myopia, high myopia, hypertropia) according to the spherical equivalent (SE), and those who met the enrollment conditions were selected as the study subjects. Multivariable logistic regression analysis was used to evaluate the relationship between refractive error and diabetic retinopathy risk.
A total of 1317 participants were included in the study, including 331 participants with diabetic retinopathy, and 986 without diabetic retinopathy. After adjustment for potential confounders, subjects with high myopia were associated with a lower risk of diabetic retinopathy. The odds ratio (OR) was 0.44, 95% confidence interval (CI): (0.20-0.96), P-value = 0.040 in the multivariate regression analysis. Subgroup analyses showed that subjects with high myopia in the non-Hispanic Black group were associated with decreased odds of diabetic retinopathy. (OR was 0.20, and 95% CI: 0.04-0.95, P-value = 0.042).
The results show that high myopia is associated with diabetic retinopathy in diabetic patients.

© 2023. The Author(s).

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ABOUT THE EXPERTS

Weijung Ten,Ying Yuan,Wei Zhang,Yue Wu,Bilian Ke

Weijung Ten

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China.

Shanghai Key Laboratory of Fundus Disease, Shanghai, China.

Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital,, Fudan University, Shanghai, China.

Ying Yuan

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China.

Shanghai Key Laboratory of Fundus Disease, Shanghai, China.

Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.

Wei Zhang

Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Yue Wu

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China.

Shanghai Key Laboratory of Fundus Disease, Shanghai, China.

Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.

Bilian Ke

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. kebilian@126.com.

Shanghai Key Laboratory of Fundus Disease, Shanghai, China. kebilian@126.com.

Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. kebilian@126.com.