High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar.

Nov 27, 2023

Experts: Fetra Angelot Rakotomalala,Julie Bouillin,Santatriniaina Dauphin Randriarimanana,Guillaume Thaurignac,Luca Maharavo,Mihaja Raberahona,Lucien Razafindrakoto,Jasmina Rasoanarivo,Mala Rakoto-Andrianarivelo,Danielle Aurore Doll Rakoto,François Xavier Babin,Tahinamandranto Rasamoelina,Eric Delaporte,Luc Hervé Samison,Martine Peeters,Eric Nerrienet,Ahidjo Ayouba

To estimate the prevalence of IgG antibodies against six arboviruses in people living with HIV-1 (PLWHIV) in Madagascar, we tested samples collected between January 2018 and June 2021. We used a Luminex-based serological assay to detect IgG antibodies against antigens from Dengue virus serotypes 1-4 (DENV1-4), Zika virus (ZIKV), West Nile virus (WNV), Usutu virus (USUV), Chikungunya virus (CHIKV), and O’nyong nyong virus (ONNV). Of the 1036 samples tested, IgG antibody prevalence was highest for ONNV (28.4%), CHIKV (26.7%), WNV-NS1 (27.1%), DENV1 (12.4%), USUV (9.9%), and DENV3 (8.9%). ZIKV (4.9%), DENV2 (4.6%), WNV-D3 (5.1%), and DENV4 (1.4%) were lower. These rates varied by province of origin, with the highest rates observed in Toamasina, on the eastern coast (50.5% and 56.8%, for CHIKV and ONNV, respectively). The seroprevalence increased with age for DENV1 and 3 ( = 0.006 and 0.038, respectively) and WNV DIII ( = 0.041). The prevalence of IgG antibodies against any given arborvirus varied over the year and significantly correlated with rainfalls in the different areas (r = 0.61, = 0.036). Finally, we found a significant correlation between the seroprevalence of antibodies against CHIKV and ONNV and the HIV-1 RNA plasma viral load. Thus, PLWHIV in Madagascar are highly exposed to various arboviruses. Further studies are needed to explain some of our findings.

Author

admin

View all posts

ABOUT THE EXPERTS

Fetra Angelot Rakotomalala,Julie Bouillin,Santatriniaina Dauphin Randriarimanana,Guillaume Thaurignac,Luca Maharavo,Mihaja Raberahona,Lucien Razafindrakoto,Jasmina Rasoanarivo,Mala Rakoto-Andrianarivelo,Danielle Aurore Doll Rakoto,François Xavier Babin,Tahinamandranto Rasamoelina,Eric Delaporte,Luc Hervé Samison,Martine Peeters,Eric Nerrienet,Ahidjo Ayouba

Fetra Angelot Rakotomalala

Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo, Antananarivo 101, Madagascar.

TransVIHMI, University of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), 34394 Montpellier, France.

Ecole Doctorale Sciences de la Vie et de l’Environnement, Université d’Antananarivo, Antananarivo 101, Madagascar.

Julie Bouillin

TransVIHMI, University of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), 34394 Montpellier, France.

Santatriniaina Dauphin Randriarimanana

Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo, Antananarivo 101, Madagascar.

Guillaume Thaurignac

TransVIHMI, University of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), 34394 Montpellier, France.

Luca Maharavo

Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo, Antananarivo 101, Madagascar.

Ecole Doctorale Sciences de la Vie et de l’Environnement, Université d’Antananarivo, Antananarivo 101, Madagascar.

Mihaja Raberahona

Service des Maladies Infectieuses, Centre Hôspitalier Universitaire Joseph Raseta de Befelatanana, Antananarivo 101, Madagascar.

Lucien Razafindrakoto

Service de Pneumo-Phtisiologie, Centre Hospitalier Universitaire Analakininina, Toamasina 501, Madagascar.

Jasmina Rasoanarivo

Secrétariat Exécutif du Comité National de la Lutte Contre le SIDA, Antananarivo 101, Madagascar.

Mala Rakoto-Andrianarivelo

Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo, Antananarivo 101, Madagascar.

Danielle Aurore Doll Rakoto

Ecole Doctorale Sciences de la Vie et de l’Environnement, Université d’Antananarivo, Antananarivo 101, Madagascar.

François Xavier Babin

Fondation Mérieux, 69002 Lyon, France.

Tahinamandranto Rasamoelina

Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo, Antananarivo 101, Madagascar.

Eric Delaporte

TransVIHMI, University of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), 34394 Montpellier, France.

Luc Hervé Samison

Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo, Antananarivo 101, Madagascar.

Martine Peeters

TransVIHMI, University of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), 34394 Montpellier, France.

Eric Nerrienet

Fondation Mérieux, 69002 Lyon, France.

Ahidjo Ayouba

TransVIHMI, University of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), 34394 Montpellier, France.