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The following is a summary of “Proteomic analysis investigating kidney transplantation outcomes- a scoping review,” published in the November 2023 issue of Nephrology by Rainey et al.
Despite advancements in kidney transplantation, there’s a need for non-invasive biomarkers to monitor graft function and predict transplant outcomes.
Researchers conducted a retrospective review to synthesize protein findings and implicated pathways from existing literature, identifying potential biomarkers for validation in independent patient cohorts.
They adhered to the Joanna Briggs’ Institute Methodology for a scoping review, searching MedlineALL, Embase, Web of Science Core Collection, Scopus, and Google Scholar databases from inception until December 2022. Two reviewers independently conducted abstract and full-text reviews using a pre-designed data extraction tool for data collection.
The results revealed 101 articles meeting the inclusion criteria. The majority consisted of single-center retrospective studies with small sample sizes. Mass spectrometry emerged as the most utilized technique for assessing differentially expressed proteins between diagnostic groups. Various candidate biomarkers, including immune or structural proteins, were identified across studies.
Investigators concluded that proteomics revealed candidate biomarkers for kidney transplantation outcomes, warranting further validation in large prospective trials.
Source: bmcnephrol.biomedcentral.com/articles/10.1186/s12882-023-03401-0
