The following is a summary of “Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics,” published in the December 2023 issue of Infectious Disease by Zhang et al.
Hepatitis B, caused by the HBV virus, poses significant challenges in treatment due to its chronic nature and the potential for severe complications, such as hepatocirrhosis and hepatocellular carcinoma. These complications impact patients physically and psychologically and impose considerable economic and societal burdens. The internalization of HBV depends on endocytosis and involves various proteins, including heparin sulfate proteoglycans, epidermal growth factor receptors, and, notably, sodium taurocholate cotransporting polypeptide (NTCP). NTCP, primarily found in the liver’s basement membrane, plays a critical role in facilitating HBV entry into cells, acting as a receptor during the process. While primarily known as a bile acid transporter, NTCP’s involvement in HBV internalization makes it a crucial target for inhibiting HBV infection. Several compounds have been identified to impede NTCP function and HBV infection, although only a few exhibit promisingly low IC50 values.
This systematic review primarily centers on comprehensively elucidating NTCP’s structure, regulation, and its role in facilitating HBV internalization. The review emphasizes the latest advancements in drug development targeting NTCP to combat HBV infection. By delving into these recent breakthroughs, this comprehensive review contributes valuable insights into the development of potent and targeted anti-HBV medications. The focus lies on shedding light on the intricate mechanisms underlying HBV entry via NTCP, highlighting the significance of this transporter as a promising therapeutic target for combating HBV infection. The insights garnered from this review offer significant promise in the pursuit of effective strategies to counter the persistent challenges posed by HBV-induced hepatitis.
Source: sciencedirect.com/science/article/abs/pii/S000629522300549X
