During preconception, pregnancy, and early childhood, multidomain interventions slightly improved child neurodevelopment at 24 months. In JAMA, investigators said that additional preconceptions of interventions’ effects on neurodevelopment are not well studied. The research team conducted a randomized trial of 13,500 participants, focusing on preconception interventions or routine care for the primary outcome of preterm births and childhood growth. The study team conducted neurodevelopment assessments in a subsample of children at age 24 months, including 509 with preconception, pregnancy, and early childhood interventions—473 with preconception interventions alone, 380 with pregnancy and early childhood interventions, and 350 with routine care. Among participants with a mean age of 23.8 years, those receiving pregnancy and early childhood interventions had higher cognitive, language, motor, and socioemotional scores and lower incidence rates in these areas. Children in the preconception, pregnancy, and early childhood intervention group had higher cognitive, language, motor, and socioemotional scores, indicating multidomain interventions lead to modest neurodevelopment in children.
