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Morita-Baylis-Hillman adduct 2-(3-hydroxy-1-methyl-2-oxoindolin-3-il) acrylonitrile (CISACN) ameliorates the pulmonary allergic inflammation in CARAS model by increasing IFN-γ/IL-4 ratio towards the Th1 immune response.

Feb 26, 2024

ABOUT THE EXPERTS

  • Larissa Adilis Maria Paiva Ferreira

    Laboratory of Immunopharmacology, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil.

    Laércia Karla Diega Paiva Ferreira

    Department of Medicine, Federal University of Alagoas, Arapiraca, AL, Brazil.

    Raquel Fragoso Pereira Cavalcanti

    Laboratory of Immunopharmacology, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil.

    Francisco Allysson de Assis Ferreira Gadelha

    Laboratory of Immunopharmacology, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil.

    Louise Mangueira de Lima

    Laboratory of Immunopharmacology, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil.

    Adriano Francisco Alves

    Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa, PB, Brazil.

    Cláudio Gabriel Lima Júnior

    Department of Chemistry, Federal University of Paraíba, João Pessoa, PB, Brazil.

    Marcia Regina Piuvezam

    Laboratory of Immunopharmacology, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil; Drug Research Institute of the Federal University of Paraíba, Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil. Electronic address: mrpiuvezam@ltf.ufpb.br.

REFERENCES & ADDITIONAL READING

PubMed

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