Early detection of adrenal abnormalities may lead to earlier diagnosis and better management of thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome, according to a study published in Biomedicines. Researchers examined the clinical and radiological imaging characteristics of adrenal abnormalities in patients with TAFRO syndrome. The 11 studies analyzed included a total of 23 patients. Histopathological analysis of lymph nodes in 15 patients confirmed TAFRO syndrome. Adrenal findings included ischemia/infarction in 11 patients, hemorrhage in nine, and adrenomegaly in four, with one showing unilateral hemorrhage and contralateral adrenomegaly. Contrast-enhanced CT showed poor enhancement in ischemic/infarcted adrenal glands, while non-enhanced CT and MRI identified high attenuation and hematomas in hemorrhagic glands, respectively. All patients exhibited adrenomegaly (100%), with frequent calcification on follow-up CT (64.3%). Abdominal pain was recorded in 15 patients (65.2%), indicating TAFRO syndrome as a potential cause of acute abdomen.