Sex may influence the development and presentation of ABCA4- associated retinopathy in patients with a mild variant of the gene, according to findings published in JAMA Opthamology. Stéphanie S. Cornelis, MSc, and colleagues conducted random-effects meta-analyses to analysis the proportion of women among individuals with ABCA4-associated retinopathy with mild and nonmild variants, including subgroup analyses for mild alleles, as well as sensitivity analyses for potentially incomplete variant identification. Women were significantly over-represented in the mild variant group ( P<0.001) compared with the nonmild variant group. Sensitivity and subgroup analyses of mild variants confirmed these disparities, and a database analysis found a higher proportion of adult women with ABCA4-associated retinopathy (652/1154) compared with those with other retinopathies (280/602). Cornelis and colleagues noted that the findings may be relevant for indicating prognosis and recurrence risk and suggested that future studies investigate whether this disparity is due to differences in disease mechanisms, healthcare-seeking behaviors, or healthcare disparities between sexes.