Obstructive sleep apnea (OSA) questionnaires for the general population may not be suitable for patients with advanced MS, according to findings published in Multiple Sclerosis and Related Disorders. Researchers analyzed oximetry data from 125 patients with advanced MS, and univariate and multivariate analyses were conducted to determine predictive factors for OSA. They also assessed a screening model that combined the Oxygen Desaturation Index (ODI) with a visual analysis method. Across an array of clinical factors, only age and snoring were significantly associated with OSA. Traditional predictive factors such as sleepiness, BMI, and sex did not show a significant association with an increased Apnea-Hypopnea Index. The ODI proved to be highly predictive of OSA ( P<0.001), accurately identifying 84.1% of patients with moderate OSA and 93.8% with severe OSA. A visual analysis model combined with ODI did not outperform ODI alone. Accord – ing to the researchers, nocturnal oximetry may be a practical, ambulatory, and accessible method for screening OSA in this population.