The Crohn’s Disease Health Index (CD-HI) is an effective patientreported outcome measure for evaluating the comprehensive impact of Crohn’s disease (CD) and has potential for validating the relevance of new therapies and supporting drug labeling, according to research published in the Journal of Clinical Gastroenterology. To develop and validate the CD-HI, Anika Varma, MD, and colleagues conducted a national cross-sectional study of individuals with CD. In a beta test involving 15 adults with CD, participants found the CD-HI to be clear, user-friendly, and relevant. Among 23 adults with CD who participated in a test-retest reliability assessment, the CD-HI demonstrated high reliability for individual questions, subscales, and the full instrument (intraclass correlation coefficient, 0.84). The CD-HI and its subscales exhibited strong internal consistency (Cronbach alpha, 0.98 for the full instrument). The CD-HI also successfully differentiated between groups with varying disease severity