Markers of diabetes are positively associated with overactive bladder (OAB), according to a study published in Frontiers in Endocrinology. Qingliu He and colleagues used data from six cycles of the US National Health and Nutrition Examination Survey (N=23,863) to examine the relationship between diabetes and OAB. The researchers found the OAB prevalence was 77% higher in participants with diabetes versus those without. With increasing quartiles of diabetes-related markers, the odds of OAB monotonically increased in three models. There was a linear association between glycohemoglobin and OAB. The associations between diabetes-related markers (glycohemoglobin, fasting glucose, and insulin) and OAB were significantly mediated by white blood cells (7.23%, 8.08%, and 17.74%, respectively) and partly mediated by neutrophils (6.58%, 9.64%, and 17.93%, respec-tively). A machine learning model showed that glycohemoglobin is the most important indicator of OAB.