The following is a summary of “Plasma concentrations of thioredoxin, thioredoxin reductase and peroxiredoxin-4 can identify high risk patients and predict outcome in patients with acute coronary syndrome: A clinical observation,” published in the May 2024 issue of Cardiology by Doughty et al.
Patients with acute coronary syndrome (ACS) often face oxidative stress. Specific biomarkers like peroxiredoxin-2 (PRDX2), PRDX4, thioredoxin (TRX), and thioredoxin reductase (TRXR) might have a crucial role in diagnosis and risk assessment.
Researchers conducted a retrospective study to verify whether biomarkers like PRDX2, PRDX4, TRX, and TRXR could help diagnose the condition and predict its severity.
They used the plasma status of 145 participants (80 ACS and 65 healthy) at diagnosis. The first follow-up was done at 1-3 months, and the second follow-up was done at 6 months and analyzed by ELISA. Patients with ACS were monitored for 12 months.
The results showed that patients with ACS had higher TRX (P<0.05), TRXR (P<0.01), and PRDX4 (P<0.01) compared to healthy donors. This increase was driven by non-ST elevated myocardial infarction for TRX (P<0.01) and PRDX (P<0.05). ACS females had higher TRXR (P<0.05), and older females (>55 years) had higher TRX (P<0.05) at diagnosis. TRX lowered at the first follow-up, but PRDX4 remained high (P<0.05). Patients receiving percutaneous coronary intervention (PCI) to suitable coronary patients had high TXRX (P<0.05), and those receiving PCI to the left anterior descending (LAD) artery had significantly higher TRXR (P<0.01) and PRDX4 (P<0.01). Patients with ACS had TRX>13.40 ng/ml at the second follow-up or TRXR<1000 pg/ml at diagnosis with LAD-PCI had a high readmission risk (P<0.05).
Investigators concluded that the levels of biomarkers such as TRX, TRXR, and PRDX4 could potentially serve as crucial indicators in identifying high-risk patients with ACS, a finding that could significantly impact the field of cardiovascular health and biomarker research.
Source: sciencedirect.com/science/article/abs/pii/S0167527324003346