Rates of prediabetes and progression to diabetes remain high among patients with HIV who are virally suppressed and on ART, according to findings published in AIDS. Mary Clare Masters, MD, and colleagues used hazards regression models to examine risk factors for the development of diabetes among participants with prediabetes (N=1,035) in the AIDS Clinical Trials Group A5322 (HAILO). At study entry, 7% of participants had prediabetes; an additional 66% developed prediabetes during follow-up. Among all participants with prediabetes (N=753), 167 people (22%) developed diabetes. In multivariable models, the risk for developing diabetes was increased with higher BMI, lower CD4 count (≤200 cells/mm 3), hypertriglyceridemia, or higher waist circumference at the time of pre-diabetes diagnosis (P<0.01). “The association between lower CD4 and progression to DM suggests a role for advanced immunodeficiency and inflammation,” Dr. Masters and colleagues wrote. “Further investigation of interventions aimed at preventing [diabetes] among [people with HIV] with [prediabetes] is needed.”