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The following is a summary of “Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy,” published in the November 2024 issue of Ophthalmology by Iovino et al. 

Researchers conducted a retrospective study to identify predictors of navigated subthreshold micropulse laser (SML) treatment in patients with chronic central serous chorioretinopathy (cCSC).  

They examined patients with cCSC who received treatment with 577 nm SML and were followed for 12 months. A thorough ophthalmological assessment, which included spectral domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and microperimetry (MP), was performed and examined FA hyperfluorescence patterns along with the SD-OCT.  

The results showed that 38 eyes from 38 patients with cCSC. Their mean age was 48.20 ± 5.95 years were included, 31 eyes (81.6%) exhibited significant subretinal fluid (SRF) reduction after treatment at 3 months, while 23 patients (60.5%) achieved complete SRF resolution at 3 months, and an additional patient (24 total, 63.2%) at 6 months, 22 (57.9%) of these individuals maintained no SRF at the end of follow-up. Best-corrected visual acuity and macular sensitivity improved significantly and progressively at all timepoints from baseline (all P < 0.005). Logistic regression analysis showed the presence of subretinal hyperreflective material (SHRM, P: 0.044; OR: -0.225; 95% CI: -0.448 – -0.003) and predicted poorer treatment response, while a focal hyperfluorescence pattern on FA (P < 0.001; OR: 0.438; 95% CI: 0.196–0.632) predicted better treatment response.   

They concluded the hyperfluorescence pattern and presence of SHRM could predict the response to SML treatment in patients with cCSC. 

Source: bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-024-03711-3