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The following is a summary of “Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy,” published in the November 2024 issue of Endocrinology by Zhang et al.
Diabetic peripheral neuropathy (DPN), the most common complication of type 2 diabetes mellitus (T2DM), occurs in individuals with diabetes and is associated with cognitive and emotional deficits. However, the neurologic mechanisms underlying these deficits are not fully understood.
Researchers conducted a prospective study investigating changes in resting-state intrinsic networks and the interaction patterns in individuals with DPN, T2DM without DPN, and HC.
They assessed neuropsychological performance and conducted resting-state functional magnetic resonance imaging (rs-fMRI) on 41 individuals with T2DM and DPN, 37 individuals with T2DM without DPN, and 43 HC. Independent component analysis was used to examine intra- and inter-network functional connectivity (FC), and relationships with clinical and cognitive variables, including Color Trails Test part 1 score, were analyzed.
The results showed decreased FC in the visual network and sensorimotor network (SMN) in individuals with DPN compared to individuals with T2DM without DPN and HCs. Individuals with DPN demonstrated decreased FC in the anterior default mode network (DMN) and increased FC in the basal ganglia network (BGN) compared to HC. Inter-network analysis revealed decreased FC between the SMN and the salience network (SN) in individuals with DPN compared to both other groups and reduced FC within the bilateral paracentral lobule (Brodmann area 6) of the SMN correlated with worse Color Trails Test part 1 scores (r=-0.302, P=0.007) and longer disease duration (r=-0.328, P=0.003) in individuals with T2DM.
They concluded that individuals with DPN have abnormal functional connectivity across multiple resting-state intrinsic networks, and decreased connectivity between the SMN and SN may underlie SM dysfunction.
Source: nature.com/articles/s41598-024-80216-5
