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The following is a summary of “Circulating miRNAs Associated With 3-Month Outcome in Patients With Acute Ischemic Stroke,” published in the December 2024 issue of Neurology by Fernández-Pére et al.
Among many individuals, post-ischemic stroke (IS) outcomes vary widely, and this variability may be linked to epigenetic mechanisms influencing recovery.
Researchers conducted a prospective study to identify microRNAs (miRNAs) associated with 3-month outcomes in people with acute IS.
They analyzed plasma samples from 215 people with IS with a mean age of 74.7 ± 10.2 years, and 54.9% were male using next-generation sequencing for 2,083 miRNAs (Q < 0.05). A replication cohort of 191 people with IS with a mean age of 78.0 ± 6.0 years, 49.7% male, was assessed using real-time polymerase chain reaction (PCR).
The results showed that after adjusting for potential confounders such as age, sex, and stroke severity (measured with the National Institutes of Health Stroke Scale [NIHSS] at 24 hours), 74 miRNAs were significantly associated with poor 3-month outcomes (Q < 0.05). In the replication cohort, 5 miRNAs (miR-376c-3p, miR-4463, miR-199a-3p, miR-584-5p, and miR-134-5p) replicated their association with poor outcomes (P<0.05, fold change > 1.7).
They concluded that 5 miRNAs may play a role in brain recovery after acute IS, with implications for predicting poor outcomes.
Source: neurology.org/doi/10.1212/WNL.0000000000210085
