Photo Credit: Photoking
The authors of a study published in Lung assessed early (1 month) and late (6 months) improvements in forced expiratory volume in 1 second (FEV1) to determine predictors of treatment response in patients with severe eosinophilic asthma (SEA). The study included 140 adults receiving systemic treatment. Early FEV1 improvement was significantly associated with low baseline FEV1 (OR, 0.54; 95% CI, 0.37-0.79) and high blood eosinophil count (OR, 1.88; 95% CI, 1.28-2.97). One-third of patients showed early and sustained FEV1 improvement, while 39% of those without early improvement exhibited progress by 6 months. High Asthma Control Test (ACT) scores at 6 months were the most reliable predictor of late response (OR, 1.75; 95% CI, 1.09-2.98). The authors concluded that predictors of systemic treatment efficacy in SEA differ depending on the timing of the response, with early improvement linked to baseline lung function and eosinophil count and late improvement linked to asthma control levels.
