Integration of clinical, pathological, radiological, and transcriptomic data improves prediction for first-line immunotherapy outcome in metastatic non-small cell lung cancer.

Jan 13, 2025

Experts: Nicolas Captier,Marvin Lerousseau,Fanny Orlhac,Narinée Hovhannisyan-Baghdasarian,Marie Luporsi,Erwin Woff,Sarah Lagha,Paulette Salamoun Feghali,Christine Lonjou,Clément Beaulaton,Andrei Zinovyev,Hélène Salmon,Thomas Walter,Irène Buvat,Nicolas Girard,Emmanuel Barillot

Immunotherapy is improving the survival of patients with metastatic non-small cell lung cancer (NSCLC), yet reliable biomarkers are needed to identify responders prospectively and optimize patient care. In this study, we explore the benefits of multimodal approaches to predict immunotherapy outcome using multiple machine learning algorithms and integration strategies. We analyze baseline multimodal data from a cohort of 317 metastatic NSCLC patients treated with first-line immunotherapy, including positron emission tomography images, digitized pathological slides, bulk transcriptomic profiles, and clinical information. Testing multiple integration strategies, most of them yield multimodal models surpassing both the best unimodal models and established univariate biomarkers, such as PD-L1 expression. Additionally, several multimodal combinations demonstrate improved patient risk stratification compared to models built with routine clinical features only. Our study thus provides evidence of the superiority of multimodal over unimodal approaches, advocating for the collection of large multimodal NSCLC datasets to develop and validate robust and powerful immunotherapy biomarkers.
© 2025. The Author(s).

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ABOUT THE EXPERTS

Nicolas Captier,Marvin Lerousseau,Fanny Orlhac,Narinée Hovhannisyan-Baghdasarian,Marie Luporsi,Erwin Woff,Sarah Lagha,Paulette Salamoun Feghali,Christine Lonjou,Clément Beaulaton,Andrei Zinovyev,Hélène Salmon,Thomas Walter,Irène Buvat,Nicolas Girard,Emmanuel Barillot

Nicolas Captier

Laboratoire d’Imagerie Translationnelle en Oncologie, Institut Curie, Inserm U1288, PSL Research University, Orsay, France. nicolas.captier@polytechnique.org.

Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France. nicolas.captier@polytechnique.org.

Marvin Lerousseau

Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France.

CBIO-center for Computational Biology, MINES ParisTech, PSL Research University, Paris, France.

Fanny Orlhac

Laboratoire d’Imagerie Translationnelle en Oncologie, Institut Curie, Inserm U1288, PSL Research University, Orsay, France.

Narinée Hovhannisyan-Baghdasarian

Laboratoire d’Imagerie Translationnelle en Oncologie, Institut Curie, Inserm U1288, PSL Research University, Orsay, France.

Marie Luporsi

Laboratoire d’Imagerie Translationnelle en Oncologie, Institut Curie, Inserm U1288, PSL Research University, Orsay, France.

Department of medical imaging, Institut Curie, Paris, France.

Erwin Woff

Laboratoire d’Imagerie Translationnelle en Oncologie, Institut Curie, Inserm U1288, PSL Research University, Orsay, France.

Department of Nuclear Medicine/PET-scan, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Sarah Lagha

Institut du Thorax Curie-Montsouris, Institut Curie, Paris, France.

Paulette Salamoun Feghali

Institut du Thorax Curie-Montsouris, Institut Curie, Paris, France.

Christine Lonjou

Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France.

Clément Beaulaton

Department of pathology, Institut Curie, Paris, France.

Andrei Zinovyev

In silico R&D, Evotec, Toulouse, France.

Hélène Salmon

Immunity and cancer, Institut Curie, Inserm U932, PSL Research University, Paris, France.

Thomas Walter

Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France.

CBIO-center for Computational Biology, MINES ParisTech, PSL Research University, Paris, France.

Irène Buvat

Laboratoire d’Imagerie Translationnelle en Oncologie, Institut Curie, Inserm U1288, PSL Research University, Orsay, France.

Nicolas Girard

Institut du Thorax Curie-Montsouris, Institut Curie, Paris, France.

Emmanuel Barillot

Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France. emmanuel.barillot@curie.fr.