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The following is a summary of “Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018,” published in the January 2025 issue of Psychiatry by Yu et al. 

Researchers conducted a retrospective study to explore the link between the systemic immune-inflammatory index (SII) and mortality in adults with depression. 

They analyzed data from adults with depression in the National Health and Nutrition Examination Survey (NHANES) (2005–2018) using Cox regression to calculate hazard ratios (HR) and 95% CIs for mortality. They applied restricted cubic spline (RCS), Kaplan-Meier curves, time-dependent ROC analysis, and subgroup and sensitivity analyses. 

The results showed that among 2,442 adults with depression (average age: 46.51 ± 0.44 years), there were 302 all-cause deaths and 74 cardiovascular deaths over a median follow-up of 89 months. An increase of 100 units in SII was linked to an HR of 1.05 (95% CI, 1.02–1.08, P = 0.003) for all-cause mortality and 1.06 (95% CI, 1.02–1.10, P = 0.004) for cardiovascular mortality. RCS analysis revealed a J-shaped relationship with all-cause mortality and a positive linear association with cardiovascular mortality. Time-dependent ROC analysis showed excellent predictive efficacy for mortality at 1, 3, 5, and 10 years. 

Investigators found that higher SII levels increased the risk of all-cause and cardiovascular mortality in adults with depression. 

Source: bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-024-06463-y