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The following is a summary of “Advancements in the Study of the Immune Molecule NKp46 in Immune System-related Diseases,” published in the November 2024 issue of Allergy and Immunology by Qian et al.
NKp46 is a receptor on NK cells and innate lymphoid cells, crucial for anti-infection and antitumor activities. Its expression is linked to the progression of immune-related diseases, infections, leukemia, tumors, and reproductive failure.
Researchers conducted a retrospective study on NKp46, a receptor on NK cells and innate lymphoid cells, crucial for anti-infection and antitumor activities.
They examined NKp46’s role in immune responses by investigating its interaction with ligands on pathogens, infected cells, and tumor cells. The study also addressed the identification of additional NKp46 ligands and their potential implications in immune modulation.
The results showed that NKp46 activates NK cells to kill infected or tumor cells, contributes to tumor immune escape inhibition and immune editing, reducing tumor growth, and correlates with immune disease progression, influencing diagnosis and prognosis.
Investigators concluded that NKp46 was crucial in immune defense and tumor control, requiring further research. Identifying additional ligands was key for advancing diagnostic and therapeutic approaches.
Source: link.springer.com/article/10.1007/s12016-024-09010-5#Abs1
