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The following is a summary of “Association of Sleep Duration With Serum Estradiol Concentrations Among American Men and Women: Evidence From NHANES 2013–2016,” published in the February 2025 issue of Endocrinology by Zhu et al. 

Researchers conducted a retrospective study to examine the relationship between sleep duration and serum estradiol concentrations, considering variations by sex and age among American adults.  

They analyzed data from 5,406 men and women aged 20 years and older (2013–2016 cycles of the National Health and Nutrition Examination Survey (NHANES), a cross-sectional study. Total estradiol levels (pg/mL) were measured and categorized as low, normal, or high (based on NHANES protocol). Sleep duration was classified into ≤ 6, 6–9, and ≥ 9 hours. Weighted multivariable-adjusted and multinomial logistic regression models assessed these associations.  

The results showed no significant associations between sleep duration and serum estradiol concentrations among American men and women. Comparisons of sleep durations (≤ 6 and ≥ 9 hours) to the reference group (6–9 hours) across different age categories yielded statistically nonsignificant odds ratios for low and high estradiol concentrations in fully adjusted models. These findings indicated that estradiol levels were not notably influenced by sleep duration variations in either sex across all age groups studied.  

Investigators concluded that sleep duration did not demonstrate a significant association with serum estradiol concentrations in a general population of American men and women, although further research is needed to explore the complex relationship between sleep and hormonal balance. 

Source: onlinelibrary.wiley.com/doi/full/10.1155/ije/7863420