Photo Credit: Megaflopp
The National Psoriasis Foundation and the American Academy of Dermatology Association note that the autoimmune chronic inflammatory skin disease, psoriasis, affects more than 3.2% of adults in the United States, representing more than 7.5 million adults.1,2 Additionally, an estimated 33.3% of those with psoriasis will also develop psoriatic arthritis.1,2 Globally, psoriasis and psoriatic arthritis affect an estimated 125 million individuals.2
The pathogenesis is both complex and multifaceted, with risk factors being classified as genetic, immunological, and environmental. 3,4 Patients with psoriasis encounter numerous health and economic burdens, and the clinical manifestations can adversely impact health-related quality of life and complications extending beyond the skin and affecting multiple systems of the body, as well as imposing psychological burdens such as depression and anxiety. 3,4 A study published in the British Journal of General Practice revealed that patients with psoriasis, especially those with severe disease, are at augmented risk of arthritis, cardiovascular disease, diabetes, and depression, and findings highlight the significance of screening for complications as a component of routine psoriasis evaluations. 5
Due to research, in recent years, gaining a greater understanding about the pathophysiology of psoriasis has resulted in the development and approval of novel targeted therapies, and other promising treatment modalities are under investigation in clinical trials.3 Additionally, research has demonstrated the importance of implementing patient-centered treatment plans to improve clinical outcomes since clinical presentation, triggers including other comorbidities, use of certain medications, and environmental /lifestyle factors, and severity vary from individual to individual.
In a recent publication in Cureus, the authors wrote, “ The management of psoriasis has entered an exciting new phase, driven by breakthroughs in novel therapies that are transforming how this complex condition is treated. Innovative options, such as biologics, selective tyrosine kinase inhibitors, and non-steroidal topicals like tapinarof and roflumilast, are providing new hope for patients, particularly those with moderate-to-severe disease. These treatments are not only more effective but also safer and better targeted, offering the potential to significantly improve the quality of life for individuals living with psoriasis.” 4 The authors added, “ The recent wave of FDA-approved treatments underscores a clear message: the future of psoriasis management lies in innovation, offering patients not just control over their symptoms but the possibility of thriving beyond the disease. 4
A recent study published in the British Journal of Nutrition discovered a significant correlation between the quality of diet and the severity of psoriasis symptoms in adults. The research analyzed data from 257 adults with psoriasis who had completed an online survey. The findings indicated that a diet of fruits and vegetables, whole grains, low-fat dairy foods, and lean meats, low in salt and sugar, is associated with reduced psoriasis severity. 6 In a press release, Sylvia Zanesco, a PhD student from the Department of Nutritional Sciences at King’s College London, who led the research, stated, “Our findings point to the potential benefits of dietary interventions in improving patient outcomes. Given the impact of psoriasis on physical and psychological well-being, incorporating dietary assessments into routine care could offer patients additional support in managing their condition.” 7
Patient Perspective
A patient diagnosed with psoriasis five years ago stated, “Living with psoriasis can be challenging at times due to frequent doctor visits, flares and costs and side effects from medications. Initially, the doctor made a lot of changes in medications, and the topical agents were often problematic and did not work for me because my psoriasis covered a large area. Three years ago, my doctor prescribed a biologic medication that helped a lot. I have learned what my triggers are and have made significant changes in my diet by not eating processed food and trying to practice relaxation techniques and exercise when I can. I have learned that having a support system in my doctor and health care team helps me, too. The pharmacist was helpful in teaching me how to inject the medication and answered all my questions about side effects. I think having a positive attitude and ensuring I care for myself helps so much.”
Looking Ahead
Tremendous advancements have been made in recognizing and treating psoriasis, which is critical since this disease remains one of the most commonly diagnosed autoimmune diseases. These advancements have the potential to enhance patient care and clinical outcomes. The availability of targeted therapies provides clinicians with safe and effective treatments to implement therapy plans tailored to patient need. Encouraging patients to take an active role in their care and being shown empathy by their healthcare providers can be instrumental in improving health-related quality of life.
