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The following is a summary of “Role of Lactate and Lactylation in the Dysregulation of Immune Responses in Psoriasis,” published in the March 2025 issue of Clinical Reviews in Allergy & Immunology by Wu et al. 

Lactate, once seen as a metabolic byproduct, functions as an immune signaling molecule through lactate shuttling. Lactylation, a post-translational modification, regulates cellular function and immune responses. 

Researchers conducted a retrospective study that showed lactate regulates pro- and anti-inflammatory pathways, influencing immune-related gene expression. This impacts immune cell differentiation, cytokine production, and the overall immune response. 

They focused on the role of lactate and lactylation in the dysregulation of immune responses in psoriasis and its relapse. 

The results showed that targeting lactate metabolism and lactylation modifications could help treat psoriasis by regulating immune responses. Artificial intelligence may advance lactate and lactylation-focused drug development, identify therapeutic targets, and enable personalized medical decision-making. 

Investigators explored how lactate and lactylation contribute to immune dysregulation in psoriasis, emphasizing their impact on metabolic and epigenetic changes. They identified the roles of these pathways in modulating immune responses and provided a foundation for developing therapeutic strategies targeting lactate metabolism and lactylation modifications. 

Source: link.springer.com/article/10.1007/s12016-025-09037-2