Abnormal white matter functional connectivity density in antipsychotic-naive adolescents with schizophrenia.

Mar 22, 2021

Contributor: Xiao Wang,Wei Liao,Shaoqiang Han,Fengmei Lu,Zongling He,Mi Yang,Xujun Duan,Jing Guo,Yan Zhang,Jingping Zhao,Huafu Chen

Abnormal white matter functional connectivity density in antipsychotic-naive adolescents with schizophrenia.

This study aimed to assess the white matter (WM) functional hubs and abnormal functional connectivity pattern in adolescents with schizophrenia (AOS) and to explore the potential mechanisms.
Based on resting-state fMRI data, we measured the WM functional connectivity density (FCD) at local- and long- ranges in 39 AOS and 31 healthy controls (HCs). Group comparison was conducted between the two groups. Spearman rank correlation analysis between the altered WM FCD and clinical PANSS scores was performed.
In the local scale, the functional hubs of the WM were mainly located in the corona radiata and cerebellum. Compared with HCs, AOS patients exhibited decreased FCD in the superior corona radiata. In the long-range, the functional hubs of the WM were mainly located in the external capsule and pons. AOS patients exhibited increased FCD in the cingulum but decreased FCD in the right dorsal raphe nuclei (DR). Furthermore, the aberrant long-range FCD in the right DR was inversely proportional to the clinical symptoms.
These findings indicated that the pathophysiology of schizophrenia may also lie in WM functional dysconnectivity.
The current results provided initial evidence for the hypothesis of abnormal WM functional connectivity in schizophrenia.

Copyright © 2021. Published by Elsevier B.V.

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About The Expert

Xiao Wang

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, PR China.

Wei Liao

The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Shaoqiang Han

The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Fengmei Lu

The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Zongling He

The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Mi Yang

The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Xujun Duan

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, PR China; The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Jing Guo

The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Yan Zhang

Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, PR China.

Jingping Zhao

Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China.

Huafu Chen

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, PR China; The Clinical Hospital of Chengdu Brain Science Institute, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China. Electronic address: chenhf@uestc.edu.cn.

References

PubMed