UV exposure to the skin disrupts the connections between fibroblasts and the extracellular matrix, resulting in collagen loss or degradation, reduced fibroblast cell density and shape, and degeneration of the elastic fiber network. Clinical degenerative changes such as wrinkles, a sallow complexion, and a loss of moisture and suppleness. With the use of natural retinol substitute bakuchiol and inorganic sunscreen actives, researchers created a photostable, broad-spectrum SPF 30 solution. For a study, they sought to research how a broad-spectrum mineral sunscreen derived from nature might enhance therapeutic results for skin with photodamage.
About 49 female participants with mild to moderate photodamage, aged 35 to 60, participated in a single-center, open-label trial. After using the natural sunscreen cream on the face at least twice daily for 6 weeks, evaluations of the product were done at the baseline and week 6. Using a 5-point ordinal scale, the dermatological investigator and participants evaluated effectiveness and tolerability (0 = none, 4 = severe). Skin hydration, barrier performance, and elasticity were all measured non-invasively.
Clinical assessments conducted by investigators revealed considerable improvements in skin laxity, fine lines, smoothness, pigmentation, and texture. Similar effectiveness was shown by the subject-rated change from baseline as the investigator. Skin moisture improved noticeably by 21%. After using the product for 6 weeks, there was a substantial 32% decrease in the retraction time (ms), indicating better skin elasticity. The operation of the skin barrier remained unaffected. Throughout the study’s course, there were no tolerability-related problems found.
Daily photoprotection using a broad-spectrum mineral sunscreen derived from nature and contains bakuchiol significantly reduced the appearance of photodamage and improved the biophysical characteristics of the skin.
Reference: jaad.org/article/S0190-9622(22)01202-6/fulltext
