The following is a summary of “Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments,” published in the November 2023 issue of Cardiology by Busby et al.
New prediction models should be evaluated in various real-world situations to ensure they benefit the people they intend to serve. Researchers performed a retrospective study to develop and validate ancestry-specific polygenic risk scores for coronary artery disease using a diverse dataset of 29,389 individuals.
The Coronary Artery Disease(CAD) Polygenic Risk Scores(PRSs) exhibited superior performance compared to previously published scores, with an average Odds Ratio(OR) per Standard Deviation of 1.57 (SD = 0.14), effectively identifying a high genetic risk in approximately 12% to 24% of individuals.
Utilizing this risk factor for reclassifying individuals with borderline or intermediate 10-year Atherosclerotic Cardiovascular Disease (ASCVD) risk-enhanced assessments for both CAD (Net Reclassification Improvement (NRI) = 13.14% (95% CI 9.23–17.06%)) and ASCVD (NRI = 10.70% (95% CI 7.35-14.05%)) in an independent cohort of 9,691 individuals.
The study found that polygenic risk scores can improve cardiovascular disease risk assessment and guide prevention.
Source: nature.com/articles/s41467-023-42897-w
