Annexin A5 is a novel prognostic biomarker in oral squamous cell carcinoma.

Jul 01, 2024

Experts: Ting Zhou,Xiaoxin Zhang,Yuxian Song,Liang Ding,Xiaofeng Huang,Lei Zhang,Chuanjin Ye,Yan Yang,Antonio Celentano,Qingang Hu,Yanhong Ni

ANXA5, a notable tumor marker, displays irregular expression in diverse solid cancers, and links to local recurrence and metastasis rates. We aimed study the expression of ANXA5 in oral squamous cell carcinoma (OSCC) and its diagnostic and prognostic values.
520 head and neck squamous cell carcinoma (HNSCC) patients in TCGA database and 124 OSCC patients in Nanjing stomatology hospital were enrolled in our study. Immunohistochemical analyses were performed using ANXA5 antibodies. Chi-square test was used to analyze the clinicopathological features. Survival rates were determined using the Kaplan-Meier method and log-rank test.
Our results showed significantly elevated ANXA5 at the gene and protein levels in HNSCC and OSCC compared to non-tumor tissues. Histopathologically, ANXA5 was broadly present in OSCC tumor cells and fibroblast-like cells but absent in tumor-infiltrating lymphocytes, particularly at the invasive tumor front. Patients exhibiting high ANXA5 expression in these cells demonstrated poor differentiation, aggressive invasion patterns, and heightened lymph node metastasis risk, contributing to poorer postoperative outcomes. Remarkably, ANXA5 in fibroblast-like cells emerged as an independent risk factor impacting survival in OSCC patients. Gene set enrichment analysis (GSEA) highlighted ANXA5’s involvement in key pathways like epithelial-mesenchymal transformation (EMT), TGF-beta signaling, and hypoxia, which correlated with adverse clinical outcomes in OSCC.
ANXA5 emerges as a significant prognostic biomarker for OSCC, potentially influencing its metastasis via the EMT pathway.

© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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ABOUT THE EXPERTS

Ting Zhou,Xiaoxin Zhang,Yuxian Song,Liang Ding,Xiaofeng Huang,Lei Zhang,Chuanjin Ye,Yan Yang,Antonio Celentano,Qingang Hu,Yanhong Ni

Ting Zhou

Department of Oral-maxillofacial Surgery, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Xiaoxin Zhang

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Yuxian Song

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Liang Ding

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Xiaofeng Huang

Department of Oral Pathology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Lei Zhang

Department of Oral Pathology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Chuanjin Ye

Department of Oral Pathology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Yan Yang

Department of Oral Pathology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Antonio Celentano

Melbourne Dental School, The University of Melbourne, Melbourne, Victoria, Australia.

Qingang Hu

Department of Oral-maxillofacial Surgery, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Yanhong Ni

Department of Oral-maxillofacial Surgery, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Research Institute of Stomatology, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.