The following is a summary of “Circadian Rhythm of Voided Volume, Maximum Flow Rate, and Voiding Time Evaluated by Toilet Uroflowmetry in Hospitalized Women With Nocturia,” published in the SEPTEMBER 2023 issue of Urology by Yoshiyama, et al.

For a study, researchers sought to investigate the circadian rhythm of urination in hospitalized women with nocturia using toilet uroflowmetry, and to assess whether this rhythm is influenced by age.

The study included 58 female patients (average age 68.4 ± 15.2 years) hospitalized for urological conditions. A total of 2,602 urinations were evaluated. Voided volume (VV) was measured as hourly averages, and maximum flow rate and voiding time were assessed. Generalized linear mixed models were employed to adjust for personal bias and age. Circadian rhythm patterns were compared between women aged <70 and those ≥70 years.

The results showed that VVs during the nighttime were significantly higher than those recorded from 06:00-07:00 (205.6 ± 11.7 ml). Maximum flow rates in the afternoon were significantly higher than those from 06:00-07:00 (18.8 ± 0.93 ml/sec). There was no statistically significant difference in voiding time at any time of the day compared to the period from 06:00-07:00. Furthermore, the study indicated that the circadian rhythm of VV became less distinct in elderly women (P interaction = 0.0057). However, no significant differences in the maximum flow rate and voiding time regarding the circadian rhythm pattern between women <70 and those ≥70 years old were observed.

The study provided clear evidence of a circadian rhythm in VV and maximum flow rate in hospitalized women with nocturia. Additionally, it suggested that the rhythm becomes less pronounced in women aged 70 and above.

Source: goldjournal.net/article/S0090-4295(23)00516-2/fulltext