The etiology of intussusception, a severe gastrointestinal obstruction, has still no evidence. Small evidence indicates that viral infection has a role to play. The IS risk was examined in the first year of life following rotavirus gastroenteritis (RV GE). IS risk has been evaluated after RV GE using United States administrative claim databases in this retrospective, self-controlled case series (SCCS). For 7 or 21 day risk periods following RV GE (main analysis) and/or after fractures, incidence ratios (IRR) of IS have been determined (sensitivity analysis). There have been 290,912,068 screenings of the subjects, 42 RV GE and IS claims and 66 fractures and IS claims. In the cycles of risk of seven and twenty-one days, the IRRs for IS after RV GE were 79.6 (95% confidential, CI 38.6–164.4) and 25.5 (95% CI: 13.2–49.2). The study of sensitivity showed that IS and fracture are associated in both periods, indicating possible confusion. The relation between the fracture and IS was not confirmed by post hoc analysis, but a possible connection between RV GE and IS was suggested. The argument databases were used to detect a temporary relationship between RV GE and IS. This relationship should be further explored due to the limitations of the data sources.
Reference: https://www.tandfonline.com/doi/full/10.1080/21645515.2020.1770514
