To observed the relationship between serum 25-hydroxyvitamin D (25-(OH) D) and different cognitive domains and evaluated the predictive value of 25-(OH) D level for cognitive impairment in patients with white matter lesions (WML).
The Mini-mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function in patients with WML. The differences in clinical data including 25-(OH) D were analysed between cognitive normality (n=87) and impairment (n=139) groups and variant cognitive domains analysed between groups of different levels of serum 25-(OH) D. And risk factors for cognitive impairments were evaluated with multivariate logistic regression analysis and receiver operating characteristic (ROC) curve of 25-(OH) D level were performed to examine the association between 25-(OH) D and WML with cognitive dysfunction. Results： As the severity of WML increased, the proportion of patients with low level of serum 25-(OH) D increased (P < 0.05) . The total MoCA scores and its all domain scores except for naming were significantly lower in patients with low levels of serum 25-(OH) D than that in patients with high levels of serum 25-(OH) D (P < 0.05). Multivariate logistic regression analyses showed that the serum 25-(OH) D levels, age, lower education level, hypertension, Systolic pressure, stroke, TC and uric acid levels were independently correlated with cognitive impairment. Conclusion：In patients with WML, low levels of serum 25-(OH) D is correlated with impairments of multiple cognitive domains and is an independent risk factor for cognitive impairment.

© 2020 The Author(s). Published by S. Karger AG, Basel.

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