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The following is a summary of “Frequency of benign tumors after partial nephrectomy and the association between malignant tumor findings and preoperative clinical parameters,” published in the August 2024 issue of Urology by Lounová et al.
Partial nephrectomy (PN) is the primary treatment for cT1 renal tumors, but some malignant-suspected tumors are found to be benign post-surgery.
Researchers conducted a retrospective study to analyze benign findings after PN and evaluate the association between malignant tumor findings and individual factors.
They included 555 patients who underwent open or robotic-assisted PN for a tumor at their clinic from January 2013 to December 2020. The cohort was divided into groups based on definitive tumor histology (malignant tumors vs benign lesions). They further evaluated the association of factors (age, sex, tumor size, R.E.N.A.L.) with the tumor’s malignant potential.
The results showed that 462 were malignant (83%) and 93 benign (17%). Malignant tumors included 66% clear-cell RCC (renal cell carcinoma), 12% papillary RCC, and 6% chromophobe RCC. Oncocytoma was the most common benign tumor at 10%, followed by angiomyolipoma at 2% and papillary adenoma at 1%. Univariate analysis revealed higher malignancy risks for males (OR 2.13, 95% CI 1.36–3.36, P=0.001), tumors larger than 20 mm (OR 2.32, 95% CI 1.43–3.74, P<0.001), and tumors with intermediate or high complexity per R.E.N.A.L. (OR 2.8, 95% CI 1.76–4.47, P<0.001). There was no association between older age and malignant renal tumor risk (P=0.878).
The study concluded that 17% of tumors were benign, with male sex, tumor size greater than 20 mm, and intermediate or high R.E.N.A.L. complexity as significant predictors of malignancy.
Source: bmcurol.biomedcentral.com/articles/10.1186/s12894-024-01543-3
