Non-invasive asthma phenotyping appears to be feasible in clinical practice, according to a study published in Biomedicines. Giorgio Ciprandi, MD, and colleagues performed a cross-sectional observational study of 503 outpatients from a single center to characterize the type 2 (T2) low, T2-high allergic asthma, and T2-high non-allergic asthma phenotypes in clinical practice. Participants were stratified based on patterns of T2 inflammation and atopic sensitization. More than one-half of patients (55.3%) had T2-high allergic asthma, 25.2% had T2-high non-allergic asthma, and 19.5% had T2-low asthma. Compared with patients with T2-low, allergic patients were younger (OR, 0.945) and weighed less (OR, 0.913), with lower smoke exposure (OR, 0.975) and residual volume/total lung capacity percentage (OR, 0.950), a higher rate of asthma severity grade 5 (OR, 2.236), more frequent rhinitis (OR, 3.491) and chronic rhinosinusitis with (OR, 2.650) or without (OR, 1.919) nasal polyps, but less frequent arterial hypertension (OR, 0.331).
