Feb 17, 2025
Glaucoma is characterised by progressive vision loss due to retinal ganglion cell deterioration, leading to gradual visual field (VF) impairment. The standard VF test may be impractical in some cases, where optical coherence...
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Immunotherapy has revolutionized the treatment landscape for head and neck squamous cell carcinoma (HNSCC) and PD-L1 combined positivity score (CPS) scoring is recommended as a biomarker for immunotherapy. Therefore, this study...
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Clear cell renal cell carcinoma (ccRCC) exhibits considerable heterogeneity, with approximately 25% of localized cases susceptible to relapse, highlighting the challenge of the absence of reliable predictive biomarkers for...
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The objective of this study was to employ machine learning to identify shared differentially expressed genes (DEGs) in prostate cancer (PCa) initiation and castration resistance, aiming to establish a robust prognostic model and...
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Establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) plays an important role in mitosis and is involved in tumor progression of human bladder and prostate cancer. However, its pathological effects on renal...
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Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis...
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The relationship between peripheral cytokines and neuroimaging biomarkers for Alzheimer’s disease (AD) is not yet well established.To determine the association of cytokine plasma levels with brain amyloid deposition,...
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The leading cause of death worldwide is cancer. Several studies suggest phenolic acids and metformin as potential cancer treatment options because of their biological and therapeutic properties. So, we synthesized some novel...
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Ultrasound therapy has turned up as a noninvasive multifunctional tool for cancer immunotherapy. However, the insufficient co-stimulating molecules and loss of peptide-major histocompatibility complex I (MHC-I) expression on...
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The use of non-medical opioids has reached 60 million in 2021. Methadone-assisted treatment (MAT) is a widely used harm-reduction strategy for opioid addiction. However, methadone can cause cognitive impairment, which can impede...
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The development of a highly sensitive electrochemical aptasensor is reported that combines the unique properties of graphene, metallic oxides, and conducting polymers to overcome the limitations of sensitivity and specificity...
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Zika virus (ZIKV) infection has emerged as a significant public health concern due to its association with fetal microcephaly and Guillain-Barre syndrome (GBS). Unfortunately, its detailed pathogenesis remains unclear. To better...
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Transgender and nonbinary young adults in the United States (U.S.) experience disproportionately high rates of HIV and face unique barriers to accessing HIV testing, a key component of HIV prevention. Gender-affirming practices...
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Chronic painful autoimmune disorders such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) induce significant discomfort. They are defined by persistent inflammation and immune-mediated...
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Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS) and a common cause for neurological disabilities in young adults. Although it is known that the peripheral immune landscape is altered...
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Fertility preservation following pediatric cancer therapy programs has become a major avenue of infertility research. In vitro spermatogenesis (IVS) aims to generate sperm from banked prepubertal testicular tissues in a lab...
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Summarize the effectiveness and safety of Semaglutide for non-diabetic obese patients through umbrella analysis.From inception to May 2024, we searched PubMed, EMbase, Web of Science, and The Cochrane Library for a systematic...
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This study investigated the long-term prognosis and clinical course of patients who survived for more than 5 years after hepatocellular carcinoma (HCC) diagnosis.This retrospective cohort study used data from the Korean National...
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Environmental pollution threatens human health and ecosystem sustainability, boosting a huge demand for filters. However, the petroleum-based filters are likewise environmentally hazardous since their non-degradability results...
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Premorbid allergic diseases are linked with the development of age-related macular degeneration (AMD), however, the risk of allergic diseases among patients with AMD is largely unknown.To evaluate the association between AMD...
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