- Physician's Weekly

BRCA1/2 pathogenic variants are associated with an increased risk of male breast, pancreatic, and stomach cancer.

Feb 1, 2022

1. Pathogenic variants of BRCA1 or BRCA2 are associated with an increased risk of pancreatic and stomach cancer in both sexes 2. Only BRCA2 carriers have an increased risk of prostate cancer Evidence Rating Level: 2 (Good) Study Rundown: Pathogenic variants (PVs) of BRCA1 and BRCA2 are known to be associated with an increased risk […]

Extreme prematurity associated with increased prevalence of visual and ocular deficits in young adults

Feb 1, 2022

1. Extreme prematurity was associated with an increased prevalence of visual and ocular deficits, suggesting children born extremely preterm may have residual ophthalmic sequelae persisting into adulthood. 2. These findings emphasized the need for screening and management of any deficits as they evolve long-term at a population-level. Evidence Rating Level: 2 (Good) Study Rundown: Although […]

Hybrid closed-loop therapy improves glycemic control for children with Type 1 Diabetes

Jan 31, 2022

1. In very young children with type 1 diabetes, a hybrid closed-loop therapy provided significantly improved glycemic children. 2. The hybrid closed-loop therapy did not significantly increase the time spent in hypoglycemia in very young children with type 1 diabetes. Evidence Rating Level: 1 (Excellent) Study Rundown: In very young children, managing Type 1 Diabetes […]

Intracranial efficacy of alectinib in ALK-positive NSCLC patients with CNS metastases

Jan 31, 2022

1. Treatment with alectinib reduced CNS lesion sizes and significantly improved symptoms, ECOG performance scores and requirements for mannitol and corticosteroids in patients with metastases from non-small cell lung cancer. Evidence Level Rating: 2 (Good) Central nervous system metastases are highly prevalent in patients with ALK gene mutations driving advanced non-small cell lung cancer despite […]

Use of different sepsis scoring systems to predict mortality in bacteremic patients

Jan 31, 2022

1. Shapiro criteria and qSOFA scores significantly predicted sepsis-related mortality in bacteremic patients. 2. Model performance measures did not strongly support the independent use of sepsis criteria to screen for bacteremia in emergency departments. Evidence Level Rating: 2 (Good) While bacteremia associated with sepsis is associated with high mortality rates, prompt identification of sepsis and […]

#VisualAbstract: Both dermatologists and patients with psoriatic disease expressed positive perspectives on strategies to improve cardiovascular disease prevention

Jan 31, 2022

Convalescent plasma is not effective at improving clinical outcomes or reducing mortality of COVID-19 patients not on mechanical ventilation

Jan 31, 2022

1. This meta-analysis found that treatment with COVID-19 convalescent plasma (CCP), compared to control group treatment, did not improve clinical outcomes, as measured by the World Health Organization clinical outcome score, or mortality. 2. There was an improvement in the mortality and clinical outcomes for participants treated with CCP who had a baseline WHO score […]

Bystander intervention may improve survival after exercise-related sudden cardiac arrest

Jan 31, 2022

1. On average, 71% of exercise-related sudden cardiac arrest (SCA) received bystander cardiopulmonary resuscitation (CPR) and 31% had an automated external defibrillator (AED) applied by a bystander. 2. The median survival rate to hospital discharge among exercise related SCA was 32% Evidence Rating Level: 1 (Excellent) Sudden cardiac arrest (SCA) is an issue affecting competitive […]