More Socioeconomic Challenges for Hispanic Women With HIV
Hispanic/Latina women receive more ancillary services than men and have similar clinical outcomes
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Author: Janine Anthes
ASA: Review Links Opioids With Complications Post-Spine Surgery
Higher postoperative pain score, worse quality of life for post-op pain management with opioids
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Cataract Surgery Tied to Drop in Cognitive Decline in Seniors
Decline in episodic memory scores seen with older age slower after versus before cataract surgery
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In NSCLC, Longer Survival With Brigatinib Than Crizotinib
Longer progression-free survival in those with ALK-positive dz who did not previously take ALK inhibitor
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β-Blockers in 1st Trimester Do Not Up Congenital Malformations
No large increase in the risk for overall, cardiac malformations in international cohort
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American College of Gastroenterology, Oct. 5-10
The American College of Gastroenterology’s 83rd Annual Scientific Meeting The annual meeting of the American College of Gastroenterology was held from Oct. 5 to 10 in Philadelphia and attracted approximately 5,000 participants from around the world, including gastroenterology and digestive specialists and other health care professionals. The conference featured presentations focusing on clinical updates in […]
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Number of Children Not Receiving Vaccines Slightly Increased
However, coverage with most recommended vaccines among children aged 19 to 35 months stable, high
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Without Medicaid Expansion, Poor Patients Forgo Medical Care
Seventeen states have not expanded Medicaid, and expansion is an election issue in several states
Read MoreCRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops.
Genome biology 2018 10 0819(1) 160 doi 10.1186/s13059-018-1531-0 Abstract BACKGROUND Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of...
Read MoreDifferential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).
Proceedings of the National Academy of Sciences of the United States of America 2018 10 08() pii 10.1073/pnas.1802166115 Abstract Programmed death-ligand 1 (PD-L1) expression on tumor cells (TCs) by immunohistochemistry is...
Read MoreEnhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.
JCI insight 2018 10 043(19) doi 10.1172/jci.insight.122467 Abstract Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) targeting neoantigens can mediate tumor regression in selected patients with metastatic...
Read MoreFirst-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1809064 Abstract BACKGROUND Enhancing tumor-specific T-cell immunity by inhibiting programmed death ligand 1 (PD-L1)-programmed death 1 (PD-1) signaling has...
Read MorePembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer.
The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810865 Abstract BACKGROUND Standard first-line therapy for metastatic, squamous non-small-cell lung cancer (NSCLC) is platinum-based chemotherapy or...
Read MoreA Not-So-New Treatment for Old Bones.
The New England journal of medicine 2018 10 01() doi 10.1056/NEJMe1812434 Abstract
Read MoreImmune checkpoint blockade therapy: the 2014 Tang Prize in Biopharmaceutical Science.
Biomedical journal 38(1) 5-8 doi 10.4103/2319-4170.151150 Abstract The first Tang Prize for Biopharmaceutical Science has been awarded to Prof. James P. Allison and Prof. Tasuku Honjo for their contributions leading to an...
Read MoreOverall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC.
The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1809697 Abstract BACKGROUND An earlier analysis in this phase 3 trial showed that durvalumab significantly prolonged progression-free survival, as compared with...
Read MoreFisetin is a senotherapeutic that extends health and lifespan.
EBioMedicine 2018 09 29() pii 10.1016/j.ebiom.2018.09.015 Abstract BACKGROUND Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated...
Read MoreBrigatinib versus Crizotinib in ALK-Positive Non-Small-Cell Lung Cancer.
The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810171 Abstract BACKGROUND Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, has robust efficacy in patients with ALK-positive...
Read MoreThe Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.
Cell reports 25(1) 80-94 pii 10.1016/j.celrep.2018.09.012 Abstract We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood...
Read MoreAllogeneic CAR-T Cells: More than Ease of Access?
Cells 2018 10 017(10) pii 10.3390/cells7100155 Abstract Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably...
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