Revising Pooled Cohort Equations Improves CVD Risk Prediction
Use of updated equations would relabel about 11.8 million high-risk U.S. adults as lower-risk
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Author: Janine Anthes
Personalized Therapy Promising in Metastatic Breast Cancer
Adaptive transfer of mutant-protein-specific tumor-infiltrating lymphocytes leads to disease regression
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ASCO: Sunitinib Alone Noninferior in Metastatic Renal Cell Cancer
Sunitinib alone noninferior to nephrectomy plus sunitinib with respect to overall survival
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ASCO: Endocrine Tx Noninferior for HR+, HER2− Breast Cancer
Similar efficacy for endocrine, chemoendocrine tx for women with midrange 21-gene recurrence score
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ASCO: mFOLFIRINOX Improves Survival in Pancreatic Cancer
And, pre-op chemoradiotherapy linked to longer overall survival than immediate surgery
Read MoreFive-Year Outcomes with PCI Guided by Fractional Flow Reserve.
The New England journal of medicine 2018 05 22() doi 10.1056/NEJMoa1803538 Abstract Background We hypothesized that fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) would be superior to medical...
Read MoreEfficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.
The New England journal of medicine 2018 05 21() doi 10.1056/NEJMoa1804093 Abstract Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13...
Read MoreDupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.
The New England journal of medicine 2018 05 21() doi 10.1056/NEJMoa1804092 Abstract Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13...
Read MoreShort-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension.
Current biology : CB 2018 05 1728(11) 1714-1724.e4 pii 10.1016/j.cub.2018.04.015 Abstract Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await...
Read MoreReview of the neurological benefits of phytocannabinoids.
Surgical neurology international 2018 04 269() 91 doi 10.4103/sni.sni_45_18 Abstract Background Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC...
Read MoreCurrent landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC).
Journal for immunotherapy of cancer 2018 05 166(1) 39 doi 10.1186/s40425-018-0349-3 Abstract Immunotherapy is among the most rapidly evolving treatment strategies in oncology. The therapeutic potential of immune-checkpoint...
Read MoreEffects of a 4-Week Very Low-Carbohydrate Diet on High-Intensity Interval Training Responses.
Journal of sports science & medicine 2018 05 1417(2) 259-268 Abstract The purpose of the study was to examine the effects of altering from habitual mixed Western-based (HD) to a very low-carbohydrate high-fat (VLCHF) diet...
Read MoreThe Effect of Two Different Concurrent Training Programs on Strength and Power Gains in Highly-Trained Individuals.
Journal of sports science & medicine 2018 05 1417(2) 167-173 Abstract The effects of concurrent strength and endurance training have been well studied in untrained and moderately-trained individuals. However, studies...
Read MoreCCR5: From Natural Resistance to a New Anti-HIV Strategy.
Viruses 2010 02 052(2) 574-600 doi 10.3390/v2020574 Abstract The C-C chemokine receptor type 5 (CCR5) is a key player in HIV infection due to its major involvement in the infection process. Investigations into the role of the...
Read MorePolo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.
Current biology : CB 2013 10 3123(22) 2255-61 doi 10.1016/j.cub.2013.09.019 Abstract Polo-like kinase 4 (Plk4) is a conserved master regulator of centriole assembly. Previously, we found that Drosophila Plk4 protein levels are...
Read MoreThe importance of stupidity in scientific research.
Journal of cell science 121(11) 1771 doi 10.1242/jcs.033340 Abstract
Read MoreRegulation of autophosphorylation controls PLK4 self-destruction and centriole number.
Current biology : CB 2013 10 3123(22) 2245-54 doi 10.1016/j.cub.2013.09.037 Abstract Polo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole...
Read MoreThe CRISPR tool kit for genome editing and beyond.
Nature communications 2018 05 159(1) 1911 doi 10.1038/s41467-018-04252-2 Abstract CRISPR is becoming an indispensable tool in biological research. Once known as the bacterial immune system against invading viruses, the...
Read MoreHabitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.
Scientific reports 2018 05 148(1) 7526 doi 10.1038/s41598-018-25919-2 Abstract Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian...
Read MoreAn Evidence-Based Approach for Choosing Post-exercise Recovery Techniques to Reduce Markers of Muscle Damage, Soreness, Fatigue, and Inflammation: A Systematic Review With Meta-Analysis.
Frontiers in physiology 2018 04 269() 403 doi 10.3389/fphys.2018.00403 Abstract The aim of the present work was to perform a meta-analysis evaluating the impact of recovery techniques on delayed onset muscle soreness (DOMS),...
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