Dysfunctional innervation might contribute to the pathogenesis of CRSwNP, but the state of the axonal outgrowth signaling in CRSwNP is unknown. The purpose of this study was to explore the axonal outgrowth pathway-related protein expression in CRSwNP.
Institutional review board-approved study in which tissue proteomes were compared between control and CRSwNP patients using an aptamer-based proteomics array confirmed by whole transcriptomic analysis.
Compared with controls, proteins associated with axonal guidance signaling pathways such as beta-nerve growth factor, semaphorin 3A, Ras-related C3 botulinum toxin substrate 1, Bcl-2, protein kinase C delta type, and Fyn were significantly decreased in patients with CRSwNP. In contrast, the reticulon-4 receptor, an inhibitory factor, was significantly increased in patients with CRSwNP. Furthermore, neuronal growth-associated proteins such as ciliary neurotrophic factor receptor subunit alpha, neuronal growth regulator 1, neuronal cell adhesion molecule, neural cell adhesion molecule L1, platelet-derived growth factor subunit A, and netrin-4 were all significantly decreased in patients with CRSwNP. Furthermore, the log FC of the studied proteins’ expression was significantly correlated with the log FC of their mRNA expression.
The study concluded that axonal guidance signaling and neural growth factor pathways are significantly suppressed in eosinophilic CRSwNP.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892418773558
